CJC-1295 w/ DAC 5MG

CJC-1295 w/ DAC 5MG is a synthetic analogue of growth hormone-releasing hormone (GHRH) that consists of the same 29-amino acid peptide backbone as CJC-1295 w/o DAC but includes an additional chemical modification known as DAC, which extends the half-life up to 8 days.

CAS Number: TP2328L (863288-34-0)
Molecular Formula: C154H256N44O44
Molecular Weight: 3427.9 g/mol
Form: Lyophilized Powder
Quantity: 5mg
Purity: ≥ 98.5% (HPLC Verified)

Key Benefits of CJC-1295 w/DAC

• Aids research into the effects of prolonged GH release
• Enables longer-duration studies due to a half-life up to 8 days
• Promotes consistent research outcomes of GH secretion
• Researchers can study the effects of GH and IGF-1 secretion
• Investigated for impacts to metabolism and tissue growth/repair
• Provides a tool for exploring GHRH-R and JAK-STAT signaling
• Lyophilized format provides consistent outcomes in laboratory settings

CJC-1295 w/ DAC 5MG, also known as DAC:GRF (short for drug affinity complex: growth hormone-releasing factor), is a synthetic analogue of growth hormone
releasing hormone (GHRH) (also known as growth hormone-releasing factor (GRF)) and a growth hormone secretagogue (GHS). CJC-1295 w/ DAC consists of the same
29-amino acid peptide backbone as CJC-1295 w/o DAC but includes an additional chemical modification known as the Drug Affinity Complex (DAC). The DAC allows
the peptide to covalently bind to serum albumin, dramatically extending its half-life up to 8 days.

CJC-1295 w/DAC binds to the GHRH receptors on the anterior pituitary gland located on the surface of somatotropic cells. Upon binding, the receptor undergoes a
conformational change that activates an associated intracellular heterotrimeric G protein.

This initiates a well-defined signaling cascade:

1. Adenylyl Cyclase Activation: The activated subunit stimulates the membrane-bound enzyme adenylyl cyclase.
2. cAMP Production: Adenylyl cyclase catalyzes the conversion of adenosine triphosphate (ATP) into the second messenger molecule cyclic adenosine
   monophosphate (cAMP).
3. PKA Activation: The accumulation of intracellular cAMP leads to the activation of cAMP-dependent Protein Kinase A (PKA).
4. CREB Phosphorylation and Gene Transcription: The activated catalytic subunits of PKA translocate into the cell nucleus. There, they phosphorylate (add a phosphate group to activate) a key transcription factor called cAMP Response Element-Binding protein (CREB). Phosphorylated CREB, along with co-activators, binds to specific DNA sequences known as cAMP response elements (CREs) located in the promoter region of the GH gene. This binding event initiates the transcription of the GH gene, leading to the synthesis of new GH messenger RNA (mRNA) and, subsequently, new GH protein.